Effect of Gamma Knife Radiosurgery in Meningioma
Iraqi Postgratuate Medical Journal,
2019, Volume 18, Issue 2, Pages 107-114
Meningioma is a common disease affects middle age patients especially females. Surgery is the first choice of treatment, gamma knife usually is a treatment for residual tumor or sometimes initially when surgery is risky.
To evaluate the short time effectiveness of gamma knife in treatment of meningioma with associated complications including necrosis and edema and assessing factors that favor success PATIENTS AND METHODS:
A retrospective study from April 2017 to October 2017 in Neurosciences hospital of 35 patients, 25 female and 10 male, age range 36-70 years, brain MRI done before and 6 months after gamma knife, patients evaluated regarding type of meningioma, number of shots, edema and radiation dose
The most common types were parasagittal and convexity meningioma, size of tumors ranged from 10mm to 57mm most tumors were 20-29mm, post-gamma necrosis was higher in non-basal meningioma (76.5%) than basal meningioma (44.4%). Necrosis appeared 100% when using > 18 Grey. The necrosis decreased when using doses 14-16 Grey and 10-12 Grey. Non-basal meningioma showed high edema (47.1%) while basal showed less edema (38.9%), higher doses of radiation associated with more edema. Headache improved post-gamma.
Gamma knife is effective and safe option to treat meningioma when surgery is risky, the tumor necrosis is highest in non-basal meningioma and when the dose above 14 grey and the peritumoral edema was highest also in non-basal meningioma and when the dose of radiation above 18 grey.
KEYWORDS: Meningioma, Gamma knife surgery, Stereotactic radiosurgery
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